December 3,  the 30th Biweekly BioMed Seminar (“Hu-BBS”) was held in the lecture Hall of School of Nursing and Health, Henan University, with the purpose of "enhancing friendship among scholars, promoting academic innovation and promoting ‘Double First-Class’ Development ". Professor Cen Juan, winner of the Outstanding Youth Fund of Henan Natural Science Foundation and Henan Key Laboratory of Natural Medicine and Immunology Engineering, was invited to give a lecture on the theme of "Pathophysiological effects of reactive oxygen Species and Drug Intervention". More than 50 experts and scholars in basic medicine, clinical medicine, pharmacy, nursing, biology, materials science, software engineering, chemistry and other disciplines attended the seminar. A number of experts and scholars, as well as postgraduate and doctoral students, participated in the on-line discussion.

According to the long-term research, Professor Cen proposed that Reactive Oxygen Species (ROS), a substance produced by cellular aerobic metabolism, are cell aerobic metabolism substance, plays an important role in the occurrence and progress of cerebral ischemia. The negative regulatory role of ROS in malignant tumors, neurodegenerative diseases and other major diseases gained a wide attention and research, but the positive regulatory role has been rarely discussed. As a key component to maintain the REDOX balance in vivo, it is extremely necessary and meaningful to study the "double-edged sword" function of ROS. Professor Cen 's unique academic views aroused great interest of the experts and scholars attending the conference.

Focusing on the international academic frontier, Professor Cen carried out academic reports mainly from two aspects: "the pathophysiological role of ROS" and "disease intervention based on the special dose-effect relationship of ROS". Multi-drug resistance (MDR) is the biggest obstacle in clinical tumor chemotherapy, and no effective treatment measures have been taken so far.  Professor Cen proposed and confirmed for the first time that ROS is an important independent mechanism for the production and maintenance of MDR. To solve the problem of multi-drug resistance from this perspective, Professor Cen believes that the first step is to establish a model and transform the prospect, and the second step is to reveal the mechanism and provide targets. Through long-term exploration, Cen-Juan's team innovatively established McF-7 /ROS and McF-7 /GSH cell lines as research models, and the research results were supported by the National Natural Science Foundation of China. Meanwhile, the natural product AA-6 extracted by Professor Cen's team has the selective effect of anti-drug resistant tumor, directly killing drug-resistant cells in the long term and reversing drug resistance in the short term, and is also a non-P-GP substrate inhibitor. The combination of the two provides a new way to overcome the multidrug resistance of malignant tumor.

According to Professor Cen, neurodegenerative diseases such as cerebral stroke, Alzheimer's disease, vascular dementia and Parkinson's disease all have pathological characteristics of oxidative stress, but the clinical medication effect is poor and there is no effective treatment. The key to solve the problem is to pay attention to the dominant signal function of ROS and precisely regulate ROS. Taking the team research results as an example, she introduced the related work carried out by her team. Firstly, a precise drug intervention model of rat cerebral ischemia was established to provide reference for individual drug use. Secondly, the use of antioxidants (depending on the difference of ROS, classification, dose-effect and space should be considered in the use of edaravone) and the regulation of P-glycoprotein and precise intervention of ROS (ROS down-regulation can specifically regulate P-GP) should be achieved. The ultimate purpose of these work is to assist doctors to accurately determine the condition of patients with cerebral ischemia, and to provide an important basis for the selection of the best treatment for patients.

Professor Cen pointed out that it is necessary to realize the rational use of drugs with the help of artificial intelligence. The instantaneous detection means of components related to ROS, the accuracy of micro detection, the difficulty of precise control, and the complexity of signal mechanism is currently the bottleneck of the ROS related studies, and this shows that the research on reactive oxygen groups has a bright future and innovative space for interdisciplinary integration.

After the report, Professor Wang Yanming, Professor Wang Lai and Professor Zhang Biao from of School of Life Sciences, Professor Duan Shaofeng and Professor Song Shiyong from school of Pharmacy, Li Bo, vice president of School of Nursing and Health, Professor Zhang Guozeng, Professor Ji Shaoping and Professor Wang Zekun from School of Basic Medicine, and Dr. Shi Jiahua and Dr. Ma Fanyi from Henan Key Laboratory of Natural Medicine and Immune Engineering, raised questions and conducted in-depth discussions with Professor Cen. Professor Cen said that, “there are still many unknown areas about ROS. I am looking forward to discussing, cooperating and improving with everyone.”

Since its inception, HU-BBS has been committed to providing interdisciplinary experts and scholars with a platform for mutual communication and collision of ideas. A large number of talented young people to be invited to make a theme report, such as Dr. Shi Bingyang, Dr Lu Fuhao, Dr Zheng Meng, Dr Yin Jinlong of School of Life Science, Dr. Lixia, Dr Wang Zekun, Dr Wang Yaohui, Dr Dr Guo Xiangqian from School of Basic Medicine, Dr. Duan Shaofeng, Dr Song Shiyong from School of Pharmacy, Dr. Yang Xiaohui and Dr. Wang Pei from School of Mathematics and Statistics, Dr. Lu Minghua from School of Chemistry and Chemical Engineering, Dr. You Datao from School of Software, Dr. Zhang Wanjun from School of Computer and Information Engineering, and Dr. Zou Xueyan from Research Center of Nanomaterials Engineering, etc. They have made remarkable innovative and landmark achievements in academic studies. They frequently sparked ideas in communication and interaction, seeking opportunities for cooperation and harvesting friendship.

Mrs. CEN Juan, doctor, professor, master and doctoral supervisor of Henan University, excellent master's degree thesis instructor of Henan Province, Young Backbone Teacher of Henan University, director of Henan Provincial Pharmacology Society. She received her bachelor's degree and doctor's degree from China Pharmaceutical University, and visited University of Colorado at Boulder for one year. She mainly focuses on the mechanism of major diseases related to reactive oxygen species and drug intervention. She has made quite some in the research of tumor multidrug resistance, regulation mechanism of P-glycoprotein in neurodegenerative diseases and drug evaluation. In recent five years, she has presided over one National Natural Science Foundation, one national study abroad fund, one outstanding youth fund of Henan Natural Science Foundation, two key project funding plans of Henan Provincial Department of education, and one graduate education reform project of Henan University; In addition, she has published 19 SCI papers in European Journal of pharmacology, European Journal of medical chemistry, oxidative medicine and cellular longevity, Chemosphere, etc., and has been granted three national invention patents as the first inventor. She also teaches pharmacology, pharmacology progress and professional English, etc.

Contribution: School of Medicine