Exploration, an international comprehensive journal published in partnership with Henan University (HENU) and Chinese Association of Nanobiology, launched by Wiley, released its first issue online.

The first issue of the first volume contains 8 papers, including 1 Editorial, 1 Perspective, 4 Research articles and 2 reviews. These papers cover the latest research achievements of researchers from 10 countries, including China, the United States, France, Japan and Germany, in nanotechnology, botany, chemistry, physics, pharmacy, energy and other disciplines, which fully reflect the positioning of this journal as a comprehensive international journal focusing on interdisciplinary research, and also the concept of “quality first”.

Guided by the national strategy of innovation-driven development, Exploration aims to provide a high-end platform for international academic communication by focusing on comprehensive research achievements and cutting-edge advances in interdisciplinary sciences and technologies that break down boundaries lies between disciplines.

Adhering to the sole criteria of innovation and scientific merit, the editorial and publishing team of Exploration aims to increase its influence in the international academic community. At the same time, the team strives to have the first impact factor (IF) of Exploration reach 15, and to make a contribution to promote the development of national scientific and technological literature publishing.

Overview of Issue 1

01 | Inaugural Editorial

Exploration: Explore a better future with advanced science and technology

Yang Liu, Bingyang Shi, Xing-Jie Liang

DOI: 10.1002/EXP.20210100

02 | Perspective

From mouse to mouse‐ear cress: Nanomaterials as vehicles in plant biotechnology

Xue Xia, Bingyang Shi*, Lei Wang, Yang Liu, Yan Zou, Yun Zhou, Yu Chen, Meng Zheng, Yingfang Zhu, Jingjing Duan, Siyi Guo, Ho Won Jang, Yuchen Miao, Kelong Fan, Feng Bai, Wei Tao, Yong Zhao, Qingyu Yan, Gang Cheng, Huiyu Liu, Yan Jiao, Shanhu Liu, Yuanyu Huang, Daishun Ling, Wenyi Kang, Xue Xue, Daxiang Cui, Yongwei Huang, Zongqiang Cui, Xun Sun, Zhiyong Qian, Zhen Gu, Gang Han, Zhimou Yang, David Tai Leong, Aiguo Wu, Gang Liu, Xiaogang Qu, Youqing Shen, Qiangbin Wang, Gregory V. Lowry, Ertao Wang, Xing-Jie Liang, Jorge Gardea-Torresdey, Guoping Chen, Wolfgang J. Parak, Paul S. Weiss, Lixin Zhang, Martina M. Stenzel, Chunhai Fan, Ashley I. Bush, Gaiping Zhang, Christopher P. L. Grof, Xuelu Wang, David W. Galbraith, Ben Zhong Tang, Christina E. Offler*, John W. Patrick*, Chun-Peng Song*

DOI: 10.1002/EXP.20210002

03 | Research Article

Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer

Juan Liu, Chao Chen, Tuo Wei, Odile Gayet, Céline Loncle, Laurence Borge, Nelson Dusetti, Xiaowei Ma, Domenico Marson, Erik Laurini, Sabrina Pricl, Zhongwei Gu, Juan Iovanna, Ling Peng*, Xing-Jie Liang*

DOI: 10.1002/EXP.20210003

04 | Research Article

Membrane-destabilizing ionizable lipid empowered imaging-guided siRNA delivery and cancer treatment

Shuai Guo, Kun Li, Bo Hu, Chunhui Li, Mengjie Zhang, Abid Hussain, Xiaoxia Wang, Qiang Cheng, Feng Yang, Kun Ge, Jinchao Zhang, Jin Chang, Xing-Jie Liang, Yuhua Weng, Yuanyu Huang

DOI: 10.1002/EXP.20210008

05 | Research Article

Mitochondria-specific nanocatalysts for chemotherapy-augmented sequential chemoreactive tumor therapy

Hui Huang, Caihong Dong,* Meiqi Chang, Li Ding, Liang Chen, Wei Feng,* and Yu Chen*

DOI: 10.1002/EXP.20210149

06 | Research Article

Receptor-targeting nanomaterials alleviate binge drinking-induced neurodegeneration as artificial neurotrophins

Jingyu Yang†, Chunxiao Wang†, Bingyang Shi, Lirong Wang, Lihuan Bai, Yuequan Shen, Liwen Huang, Xiaohang Che, Zhen Zhang, Ping Liu, Yanan Zhao, Xiaomei Hu, Xing-Jie Liang, Chunfu Wu*, Xue Xue*

DOI: 10.1002/EXP.20210004

07 | Review

Nanozyme for tumor therapy: Surface modification matters

Guoheng Tang, Jiuyang He, Juewen Liu, Xiyun Yan*, Kelong Fan*

DOI: 10.1002/EXP.20210005

08 | Review

Self-powered technology based on nanogenerators for biomedical applications

Yuanzheng Zhang, Xiangyang Gao, Shishang Guo*, Haiwu Zheng*, Yonghui Wu, Zhong Lin Wang*

DOI: 10.1002/EXP.20210152