Cancer remains to be a serious threat to human health all over the world because of its high morbidity and mortality. Nanoscale drug delivery system (nDDS) mediated combinatorial therapy shows great promise in cancer treatment to circumvent the drawbacks of conventional monotherapy. Recent studies have shown that combinatorial cancer therapy could exert synergetic efficacy and minimize the side effects through multipronged actions to cancer, which has become a promising research and treatment strategy.
We reported the development of a supramolecular self-assembly strategy to construct multifunctional nDDS. Cisplatin pro-drug (Pt-CD) was successfully loaded onto polydopamine nanoparticles (PDA NPs) through the host-guest supramolecular self-assembly between β-cyclodextrins (β-CD) and adamantyl groups. PDA-Pt NPs exhibited photoacoustic imaging capacity for real-time in vivo monitoring of the accumulation of the nanodrug in the tumor site and facilitated the imaging-guided PTT at the optimal treatment window. (Fabrication of cisplatin-loaded polydopamine nanoparticles via supramolecular self-assembly for photoacoustic imaging guided chemo-photothermal cancer therapy. Appl. Mater. Today 2021, https://doi.org/10.1016/j.apmt.2021.101019 IF:10.041)
Recently, cisplatin prodrug (Pt-CD) and a mitochondria-targeted near-infrared (NIR) photosensitizer IR780 were combined to construct a multifunctional nanomedicine IR780@Pt NPs through a supramolecular self-assembly strategy. IR780@Pt NPs exhibited excellent NIR fluorescence and photoacoustic (PA) imaging capacity for in vivo imaging-guided NIR laser treatment. And the IR780@Pt NPs mediated combinatorial chemophototherapy achieved potentiated anticancer efficacy against cancer cells in vitro and tumor inhibition performance in vivo. Overall, this study highlighted the significance of nanomedicine mediated targeted induction of mitochondrial dysfunction to potentiate chemotherapy for efficient combinatorial cancer therapy. (Engineering supramolecular nanomedicine for targeted near infrared-triggered mitochondrial dysfunction to potentiate Cisplatin for efficient chemophototherapy. ACS Nano 2021, https://doi.org/10.1021/acsnano.1c09555 IF:15.881)
Prof. Mei-Xia Zhao from Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, is the corresponding author of these papers. This work was supported by Henan University, the National Natural Science Foundation of China (21501044), Key Scientific and Technological Project of Henan Province (212102311018), Major Cultivation Project of First-class Discipline of Henan University (2019YLZDJL09), and Special Professor Project of Henan University.
(From: Joint national laboratory for antibody drug engineering)
