Brain-targeted CRISPR/Cas9 nanomedicine for effective glioblastoma therapy

Utilizing the high specificity and efficiency of CRISPR gene editing technology, the lab developed a new polymer nanocarrier, which can significantly improve the encapsulation and loading of Cas9 RNP components by modifying guanidine and fluoro groups. The prepared nanoparticles can cross blood-brain barriers (BBB) with ease, demonstrating superior blood circulation time, cellular uptake, and d...